This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate. Some people taking Xeljanz get tears in their stomach or intestine. Tell your healthcare provider if you have had diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines. Tears (perforation) in the stomach or intestines. Some people who have taken Xeljanz with certain other medicines to prevent kidney transplant rejection have had a problem with certain white blood cells growing out of control (Epstein Barr Virus-associated post transplant lymphoproliferative disorder).Tell your healthcare provider if you have ever had any type of cancer. Lymphoma and other cancers can happen in patients taking Xeljanz.Ask your healthcare provider if you do not know if you have lived in an area where these infections are common.Ĭancer and immune system problems. Xeljanz may increase your risk of certain cancers by changing the way your immune system works. These infections may happen or become more severe if you use Xeljanz. live or have lived, or have traveled to certain parts of the country (such as the Ohio and Mississippi River valleys and the Southwest) where there is an increased chance for getting certain kinds of fungal infections (histoplasmosis, coccidioidomycosis, or blastomycosis).have TB, or have been in close contact with someone with TB.People with these conditions have a higher chance for infections. have diabetes, HIV, or a weak immune system.get a lot of infections or have infections that keep coming back.burning when you urinate or urinating more often than normal.warm, red, or painful skin or sores on your body.think you have an infection or have symptoms of an infection such as:.You should not start taking Xeljanz if you have any kind of infection unless your healthcare provider tells you it is okay.īefore starting Xeljanz, tell your healthcare provider if you: Your healthcare provider should monitor you closely for signs and symptoms of TB infection during treatment with Xeljanz. Your healthcare provider should test you for TB before starting Xeljanz.Some people have died from these infections. Some people have serious infections while taking Xeljanz, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Serious infections. Xeljanz can lower the ability of your immune system to fight infections. Tell your healthcare provider if you have any of the following symptoms of a possible hepatitis B or C infection: Hepatitis B or C activation infection in people who carry the virus in their blood.
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